gene_symbol
CD274
hgnc_id
HGNC:17635
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Avelumab binds PD-L1 and its IgG1 Fc engages Fc-gamma receptors on NK cells to trigger ADCC (and possibly ADCP), directly killing PD-L1–expressing cells; it also restores T-cell killing via PD-1/PD-L1 blockade.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Immune checkpoint ligand expressed on tumor and immune cells; blockade restores T-cell activity and enables ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05947500
disease_id_num_tar_ref
571
drug_id_num_tar_ref
1586