gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Glofitamab binds CD3 on T cells to activate them and bridge to CD20 on B cells, leading to T cell–mediated perforin/granzyme killing of CD20+ cells; CD3+ cells are effectors, not targets of killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Monovalent CD3 binding (T-cell engager)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06213311
disease_id_num_tar_ref
573
drug_id_num_tar_ref
1591