gene_symbol
IL10RB
hgnc_id
HGNC:5965
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The CAR-NK cells specifically recognize CD19 and lyse CD19+ cells via NK degranulation (perforin/granzyme). IL-10 receptor beta is not targeted, so its expression does not trigger killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
IL-10 signals through the IL10RA/IL10RB receptor complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06707259
disease_id_num_tar_ref
1
drug_id_num_tar_ref
1