gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD38 IgG1 binds CD38 and triggers Fc-mediated ADCC by NK cells, ADCP by phagocytes, and complement-dependent cytotoxicity; can also induce apoptosis of CD38+ cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II transmembrane ectoenzyme (NADase/ADP-ribosyl cyclase) expressed on plasma cells and immunosuppressive subsets
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06627309
disease_id_num_tar_ref
575
drug_id_num_tar_ref
1598