gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds TROP2 on target cells, is internalized, and releases SN-38, a topoisomerase I inhibitor that causes DNA damage and apoptosis; released payload can also exert a bystander effect on neighboring cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface transmembrane glycoprotein; ADC antibody component binds
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06243393
disease_id_num_tar_ref
576
drug_id_num_tar_ref
1602