gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Infused autologous TILs use native TCRs to recognize the neoantigen peptide–HLA class I complex on tumor cells and directly kill them via perforin/granzyme-mediated cytolysis (and Fas–FasL apoptosis).
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–MHC (pMHC) class I complex on tumor cells; TCR-restricted
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06190275
disease_id_num_tar_ref
580
drug_id_num_tar_ref
1617