gene_symbol
GUCY2C
hgnc_id
HGNC:4688
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-GCC CAR-T cells bind GCC on target cells, form an immune synapse, and kill via perforin/granzyme-mediated lysis (and ancillary cytokine/Fas–FasL signaling).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CAR scFv binds extracellular GCC on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06653010
disease_id_num_tar_ref
593
drug_id_num_tar_ref
1668