gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
BCMA-specific CAR T cells bind BCMA, become activated via CD3ζ/costimulation, and kill BCMA+ cells through perforin/granzyme cytolysis and death-receptor–mediated apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Dual CAR co-expression; activation upon BCMA binding (OR logic with CD19).
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06097455
disease_id_num_tar_ref
595
drug_id_num_tar_ref
1674