gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
XmAb541 binds CD3 on T cells to activate and recruit them to CLDN6+ tumor cells; the T cells then kill the CLDN6-expressing tumors (perforin/granzyme-mediated cytotoxicity). CD3+ cells themselves are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
monovalent binding
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06276491
disease_id_num_tar_ref
596
drug_id_num_tar_ref
1675