gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Obinutuzumab targets CD20 on B cells; its Fc binds FcγRIIIa (CD16a) on NK cells/monocytes to trigger ADCC/ADCP that kills CD20+ cells. CD16a-expressing effector cells are not targeted or killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated engagement; glycoengineering enhances affinity and ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06054776
disease_id_num_tar_ref
597
drug_id_num_tar_ref
1677