gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds TROP2 on tumor cells, is internalized, and releases a topoisomerase I inhibitor that causes DNA damage and apoptosis; DNA topoisomerase I is the intracellular payload target, not the antigen used for cell targeting.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Payload enzymatic target (topoisomerase I inhibitor)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06428409
disease_id_num_tar_ref
607
drug_id_num_tar_ref
1699