gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The IgG1 antibody binds EGFR on target cells and its Fc engages Fc gamma receptors on immune effectors (e.g., NK cells, macrophages) to trigger ADCC, killing EGFR-positive cells; EGFR blockade can also promote apoptosis/growth arrest.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds the extracellular ligand-binding domain of EGFR to block ligand interaction
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06722911
disease_id_num_tar_ref
609
drug_id_num_tar_ref
1708