gene_symbol
TNF
hgnc_id
HGNC:11892
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Infliximab binds transmembrane TNF-α on activated immune cells; its IgG1 Fc recruits effector functions (ADCC by NK/myeloid cells and CDC) and crosslinking of tmTNF triggers reverse-signaling–mediated apoptosis of the TNF-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds membrane TNF; can trigger reverse signaling/apoptosis in TNF-expressing cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06614387
disease_id_num_tar_ref
612
drug_id_num_tar_ref
1715