gene_symbol
CD79B
hgnc_id
HGNC:1699
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds CD79b on B cells, is internalized, and releases MMAE via a cleavable linker to inhibit tubulin polymerization, leading to G2/M arrest and apoptosis of CD79b-positive cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC antibody component; target on B cells; internalization enables MMAE release
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06554600
disease_id_num_tar_ref
614
drug_id_num_tar_ref
1719