gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells recognize CD19 via the tandem nanobody CAR, activate CD3z/costimulatory signaling, and kill CD19+ cells through perforin/granzyme-mediated cytolysis (and death-receptor pathways).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
tandem dual nanobody (VHH) CAR target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06880913
disease_id_num_tar_ref
629
drug_id_num_tar_ref
1762