gene_symbol
CD22
hgnc_id
HGNC:1643
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells bind CD22 via the tandem CAR, triggering T-cell activation and perforin/granzyme-mediated killing (with possible Fas/FasL apoptosis) of the target cell.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
tandem dual nanobody (VHH) CAR target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06880913
disease_id_num_tar_ref
629
drug_id_num_tar_ref
1762