gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Elranatamab binds CD3ε on T cells and BCMA on myeloma cells to form an immune synapse; the activated T cells release perforin/granzymes to kill BCMA+ tumor cells, not the CD3+ T cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Component of the T-cell receptor-CD3 complex on T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06479954
disease_id_num_tar_ref
631
drug_id_num_tar_ref
1766