gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD19-directed CAR T cells bind CD19 on target B cells, activate via CD3ΞΆ/co-stimulatory signaling, and kill through perforin/granzyme-mediated cytolysis (and Fas/FasL apoptosis), with cytokine release supporting cytotoxicity.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06393335
disease_id_num_tar_ref
643
drug_id_num_tar_ref
1796