gene_symbol
BCL2
hgnc_id
HGNC:990
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
BH3-mimetic binds and inhibits BCL-2, releasing BAX/BAK to induce mitochondrial outer membrane permeabilization and caspase-dependent intrinsic apoptosis in target-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
BH3-binding groove (hydrophobic pocket); BH3-mimetic inhibitor
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06516978
disease_id_num_tar_ref
647
drug_id_num_tar_ref
1811