gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2 on target cells, is internalized, and releases MMAE, which inhibits tubulin polymerization, leading to G2/M arrest and apoptosis of HER2-expressing cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC antibody component; binds extracellular domain on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06389006
disease_id_num_tar_ref
651
drug_id_num_tar_ref
1819