gene_symbol
BCL2
hgnc_id
HGNC:990
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Venetoclax directly inhibits BCL-2, releasing pro-apoptotic BH3-only proteins to activate BAX/BAK, trigger mitochondrial outer membrane permeabilization, cytochrome c release, and caspase-dependent apoptosis in BCL-2–dependent cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
BH3-mimetic binding to the BH3 (hydrophobic) groove
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06571825
disease_id_num_tar_ref
654
drug_id_num_tar_ref
1827