gene_symbol
CD70
hgnc_id
HGNC:11937
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD70-specific CAR T cells bind CD70 on target cells and, upon CAR activation (CD3ΞΆ + costimulation), kill them via perforin/granzyme-mediated cytolysis (and death receptor pathways).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
membrane-bound extracellular domain on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06828341
disease_id_num_tar_ref
2
drug_id_num_tar_ref
4