gene_symbol
TNFRSF4
hgnc_id
HGNC:11918
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Afucosylated IgG1 anti-OX40 engages Fc receptors (e.g., FcγRIIIa) on NK cells to trigger ADCC, with possible macrophage ADCP, depleting OX40+ activated T cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Antagonizes OX40–OX40L signaling; afucosylated Fc enhances ADCC against OX40+ T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06268860
disease_id_num_tar_ref
681
drug_id_num_tar_ref
1906