gene_symbol
FGFR2
hgnc_id
HGNC:3689
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-FGFR2b antibody–drug conjugate binds FGFR2b on target cells, is internalized, and releases a topoisomerase I inhibitor payload that disrupts DNA replication, causing cell cycle arrest and apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
cell-surface receptor; internalization mediates ADC uptake
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06625593
disease_id_num_tar_ref
687
drug_id_num_tar_ref
1916