gene_symbol
BCL2
hgnc_id
HGNC:990
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Venetoclax binds and inhibits BCL-2 (BH3 mimetic), disabling its anti-apoptotic function and freeing pro-apoptotic effectors to trigger MOMP, cytochrome c release, caspase activation, and apoptosis in BCL-2–dependent cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds the BH3 (hydrophobic) groove of the anti-apoptotic protein to restore mitochondrial apoptosis
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06387121
disease_id_num_tar_ref
693
drug_id_num_tar_ref
1932