gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Mosunetuzumab engages CD3 on T cells to activate and redirect them to kill CD20+ B cells via immune synapse formation and perforin/granzyme-mediated lysis; CD3+ T cells are not the cytotoxic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Component of TCR-CD3 complex on T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05672251
disease_id_num_tar_ref
713
drug_id_num_tar_ref
1979