gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine primes neoantigen-specific CD8+ cytotoxic T cells (with CD4+ T-cell help). CTLs recognize neoantigen peptides on MHC I of tumor cells and kill them via perforin/granzyme or Fas–FasL; CD4 T cells may also kill MHC II–positive tumor cells.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Personalized set of somatic mutation-derived peptides; presented by patient HLA class II; recognized by CD4+ T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06631092
disease_id_num_tar_ref
718
drug_id_num_tar_ref
1990