gene_symbol
TNFRSF5
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Mitazalimab binds CD40 on target cells and its IgG1 Fc engages FcγR+ effector cells (e.g., NK cells, macrophages) to mediate antibody-dependent cellular cytotoxicity (ADCC), killing CD40+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
agonist
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06205849
disease_id_num_tar_ref
724
drug_id_num_tar_ref
2010