gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD19 CAR-T cells recognize CD19 and directly kill target cells via T-cell cytotoxic mechanisms, primarily perforin/granzyme-mediated apoptosis (and death-receptor pathways).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
FMC63-defined epitope on the extracellular domain; HLA-independent recognition
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06227026
disease_id_num_tar_ref
728
drug_id_num_tar_ref
2022