gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
SHR-A1811 targets HER2, not topoisomerase I, for cell selection. HER2+ cells internalize the ADC; the released camptothecin payload inhibits topoisomerase I, causing DNA damage and apoptosis. Topoisomerase I expression alone does not make cells directly targeted.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
camptothecin-derived payload (rezetecan) stabilizes TOP1–DNA cleavage complexes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06123494
disease_id_num_tar_ref
745
drug_id_num_tar_ref
2064