gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 antibody binds HER2 and recruits FcγR-expressing effector cells (e.g., NK cells) to kill via ADCC; HER2 dimerization blockade also suppresses survival signaling, promoting apoptosis.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain II (dimerization domain) to block HER2 heterodimerization, especially HER2/HER3
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06510465
disease_id_num_tar_ref
89
drug_id_num_tar_ref
232