gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells bind CD19 on target cells, activate via CD3ζ/4-1BB, form an immune synapse, and kill CD19+ cells primarily through perforin/granzyme-mediated cytolysis (and Fas–FasL apoptosis).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06481241
disease_id_num_tar_ref
748
drug_id_num_tar_ref
2074