gene_symbol
FOLR1
hgnc_id
HGNC:3791
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
An FRα-targeting antibody–drug conjugate binds FRα, is internalized, and releases the DM4 payload via cleavable linker reduction; DM4 inhibits microtubule assembly, causing mitotic arrest and apoptosis (with possible bystander effect).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
GPI-anchored cell-surface receptor; ADC internalization enables payload release
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06365853
disease_id_num_tar_ref
757
drug_id_num_tar_ref
2107