gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Cells are not killed based on β-tubulin expression itself. The ADC binds FRα, is internalized, and releases DM4, which then binds β-tubulin to inhibit microtubules, causing mitotic arrest and apoptosis (with possible bystander killing).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
DM4 maytansinoid payload binds β-tubulin to inhibit microtubule assembly
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06365853
disease_id_num_tar_ref
757
drug_id_num_tar_ref
2107