gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
DP303c targets HER2 on tumor cells; after HER2-mediated internalization, a cleavable linker releases MMAE that binds beta-tubulin to inhibit microtubule polymerization, causing G2/M arrest and apoptosis. Beta-tubulin is not the antigen recognized for targeting.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular target of MMAE payload; binds vinca site to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06313086
disease_id_num_tar_ref
767
drug_id_num_tar_ref
2136