gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2 on target cells, is internalized, and releases DM1 intracellularly to inhibit microtubules, causing mitotic arrest and apoptosis; trastuzumab Fc can also mediate ADCC against HER2+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Trastuzumab component binds the extracellular domain (subdomain IV) of HER2 and mediates ADCC.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06313086
disease_id_num_tar_ref
767
drug_id_num_tar_ref
2137