gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
T-DM1 binds HER2 and is internalized; the DM1 payload then binds beta-tubulin to disrupt microtubules, causing mitotic arrest and apoptosis. Beta-tubulin expression alone does not make cells targets for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
DM1 payload binds tubulin to disrupt microtubule dynamics after internalization.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06313086
disease_id_num_tar_ref
767
drug_id_num_tar_ref
2137