gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab–IR700 binds EGFR on tumor cells; local 690 nm light activates IR700, causing rapid membrane disruption and immunogenic cell death selectively in EGFR-expressing cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cytotoxic effect requires 690 nm light activation of IR700 after EGFR binding
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06699212
disease_id_num_tar_ref
784
drug_id_num_tar_ref
2183