gene_symbol
IL2RB
hgnc_id
HGNC:6009
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
IL‑2/IL‑15Rβ is not targeted; IL‑15 from the engineered NK cells signals through this receptor on the NK cells to support survival. Cytotoxicity is directed at TROP2+ tumor cells via CAR-triggered NK perforin/granzyme killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Signaling subunit of IL-15 receptor complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06066424
disease_id_num_tar_ref
791
drug_id_num_tar_ref
2199