gene_symbol
IL2RG
hgnc_id
HGNC:6010
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
IL-2RG (common gamma chain) is not the CAR target; it functions in IL-15 signaling on the engineered NK cells. Killing is directed to TROP2+ cells via CAR-triggered NK perforin/granzyme cytotoxicity.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Shared signaling subunit for IL-2/IL-15 receptor complexes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06066424
disease_id_num_tar_ref
791
drug_id_num_tar_ref
2199