gene_symbol
GPC3
hgnc_id
HGNC:4451
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Native TCR recognition of GPC3-derived peptide presented on MHC triggers TIL activation and cytotoxic granule release (perforin/granzyme) and death-receptor signaling, killing the target cell.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Presented by HLA class I and/or II on HCC cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06463522
disease_id_num_tar_ref
94
drug_id_num_tar_ref
243