gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on target cells and its IgG1 Fc engages FcγR-expressing effector cells (e.g., NK cells) to mediate ADCC (and possibly CDC), killing EGFR+ cells; EGFR blockade itself is mainly cytostatic.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular ligand-binding domain (domain III), blocking ligand binding and receptor dimerization; IgG1 Fc can engage Fcγ receptors to mediate ADCC.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06005324
disease_id_num_tar_ref
800
drug_id_num_tar_ref
2224