gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds Trop-2 (not topoisomerase I), is internalized, and releases SN-38, which inhibits topoisomerase I to cause DNA damage and apoptosis; thus killing is driven by Trop-2–mediated delivery, not by expression of topoisomerase I itself.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Direct enzymatic target of SN-38 payload (ADC)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06040970
disease_id_num_tar_ref
805
drug_id_num_tar_ref
2237