gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-HER2 bispecific IgG binds HER2 on target cells and engages Fcγ receptors on NK cells/macrophages to trigger antibody-dependent cellular cytotoxicity (ADCC), leading to lysis/apoptosis of HER2+ cells; also blocks HER2 signaling.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Bispecific antibody binds two non-overlapping epitopes on HER2 extracellular domain (domains II and IV), blocking dimerization and signaling; mediates Fcγ-dependent ADCC.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05838066
disease_id_num_tar_ref
807
drug_id_num_tar_ref
2240