gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti‑HER2 IgG1 binds HER2 and engages Fcγ receptors on NK cells/other effectors to trigger ADCC, killing HER2+ cells; HER2 signaling blockade can also promote apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular subdomain II (dimerization domain) to block HER2 homo-/heterodimerization; IgG1 Fc can mediate ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05838066
disease_id_num_tar_ref
807
drug_id_num_tar_ref
2242