gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds HER2 on target cells and engages Fcγ receptors on effector cells (e.g., NK cells) to trigger antibody‑dependent cellular cytotoxicity, killing HER2+ cells (with some complement activation possible).
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain IV of HER2; IgG1 mediates Fc-gamma–dependent ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05838066
disease_id_num_tar_ref
807
drug_id_num_tar_ref
2243