gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds CD30 on target cells; after internalization, MMAE is released and binds the beta‑tubulin (vinca) site to disrupt microtubules, causing G2/M arrest and apoptosis. Cells are selected for killing by CD30 expression, not by beta‑tubulin.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
intracellular target of MMAE payload; microtubule polymerization inhibitor
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06393361
disease_id_num_tar_ref
814
drug_id_num_tar_ref
2261