gene_symbol
TIGIT
hgnc_id
HGNC:26838
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Fc-enabled IgG1 binds TIGIT on target cells and engages FcγR-expressing effectors (e.g., NK cells, macrophages) to mediate ADCC/ADCP, depleting TIGIT+ cells (notably TIGIT+ Tregs).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks TIGIT interaction with CD155 (PVR) and CD112 (NECTIN-2; PVRL2)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06062420
disease_id_num_tar_ref
818
drug_id_num_tar_ref
2268