gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells bind CD20 via the tandem CAR, become activated through CD3ΞΆ/4-1BB signaling, and kill CD20+ cells via perforin/granzyme-mediated cytolysis (and death-receptor pathways).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
tandem scFv bispecific CAR (OR logic); B-cell surface antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06503094
disease_id_num_tar_ref
828
drug_id_num_tar_ref
2293