gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD19-directed CAR T cells bind CD19 on target cells and, upon CD28/CD3ζ signaling, directly kill CD19+ cells via T-cell cytotoxic mechanisms (perforin/granzyme release and Fas–FasL–mediated apoptosis).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface antigen on malignant and normal B cells
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06447987
disease_id_num_tar_ref
837
drug_id_num_tar_ref
2309